Long-time-lurker first-time-poster. I'll describe the issue, what solutions/workarounds I've tried, my setup, and hopefully someone will know something. I've been using DP10 for about a year and have had plenty of issues that I've solved from previous threads.
The issue this time is that overnight/after a shutdown, I started receiving the following error on all my sessions (not blank ones):
Mas, 1 error reported by Mas Audio Unit Support
Failure Base:::[different numbers, sometimes -1, sometimes -50]
I looked into threads here and it seemed like it was an issue with plugins, licenses, and programs not being on the same drive. However, I have everything on the same SDD (internal). I went back and rescanned my plug-ins, and found that many were disabled. I tried rescanning individual plugins (VST2, 3, and AU) and they repeatedly failed. So I scanned them all. The majority of my plugins are suddenly failing the examination. I want to reiterate that they worked (at this point) less than 48 hours ago. Kontakt works, but some of my iZotope plugins fail, some don't, all of my spitfire plugins that have their own launchers fail, garritan, eastwest, cymatics, ample sounds, etc. So, I deleted the pref. files, cleared the trashed, restarted, reloaded, scanned again. Still same issue. I then restored a backup from a week ago when everything worked, scanned again, deleted preferences, restarted, scanned again. Still same issue.
//I'm trying a clean install of DP10 as we speak but my hopes are low.
EDIT: I've now freshly installed 10, UVI workstation, all of the instruments again, and re-updated to 10.13. Still same issue.
EDIT2: I've reinstalled a small selection of my plug-ins that used to work, they again fail examination but I enable them anyway. When I attempt to add them into a channel/instrument, they don't appear even when searching (restarted DP, cleared preferences, restarted computer).
My specs:
DP10.13
OSX 10.12.6
MacbookPro mid 2012
2.3 GHz Intel Core i7
8 GB RAM 1600 MHz DDR3 (I know, I know

Intel HD Graphics 4000 1536 MB
My interface is a Focusrite Scarlett Solo 2i2, subbed in a replacement cable just in case that's the issue but still no dice.
Any ideas?