My audio driver setup in DP is as follows (configurable options descending):
Asio > M-Audio USB ASIO > 44100 > Internal > Override Internal Buffer unchecked > 256 > Priority Boost checked
I've tried disabling priority boost, playing around with latency (I have this issue at 512 samples as well).
EDIT: I'm having issues at any latency (1024, 2056). Plugins will not playback on recorded MIDI notes, stuttering, notes triggering out of time, etc.

I'm using the midiman and a Kawai K4 keyboard as my MIDI controller. I will load an instrument track with a MIDI track outputting to it and I'll record my MIDI performance, and then I'll stop and playback the entire track and my Model 12 track will have dropped out. It's not muted and nothing is solo'd at this point. I'll have to exit DP and restart it or change my audio driver to something else and change it back to the working driver for Model 12 to start working again. This behavior seems to also occur when I have a segment looping for a while. My project only has a handful of tracks currently so I'm not even at 25% cpu utilization.
Another issue I'll have that I can replicate every time is when I'm switching through presets in Modulo. At some point, the audio engine will start to crap out and most of the presets will start to sound like bit-crushed static'y garbage. I can't figure it out. I've been producing with this hardware setup for a while now. I've used other daws which don't have this issue on my system.
Any thoughts? I really like DP's workflow and I used to be a DP7 user when I was in the Mac ecosystem a couple of years ago. I just can't produce longer than 30 minutes right now without having to troubleshoot audio playback issues.