Don't panic for one!
Startup DP holding the option key and disable all plugs. Then try enabling the plugs from the DP preferences. That will force DP to reexport the audio system.
If that doesn't work, remove the plugs from the system plugin folder (library>audio) and start DP. Quit DP and move the plugs back and start DP again. That will force a reexamination of the plugs.
If that fails, reinstall MachFive. You might also pitch the plists for DP and MachFive as well.
I had the original ExtremeFX as well and skipped that install from the M5 disk without a problem and I don't that is an issue. Were you ever able to see ExtremeFX in MachFive? Did it go south after that or are we talking about initial setup in M5?