I've just spent almost an hour on tech support to MOTU and they've been no help really trying to get my Motu 828 MKII USB 2 up and running again.
I'm running a PowerMac G5 Dual 2GHz, and upgraded from os x 10.4 to 10.5 today. Everything was working fine in 10.4 this morning.
Since trying to load up things like Logic, Ableton etc... I noticed the drivers weren't being recognized anymore, and sound could not even be output in things like iTunes or Quicktime to the 828. Only now the internal/built in audio.
I went to the motu.com site, and noticed the driver needs updating. So I ran the download, and hoped everything would be fine.
However, it made no difference.
The hardware comes up listed in the System Output pane.
The Audio MIDI utility will recognize the hardware okay, and can interface with it changing the clock rate okay.
Cuemix however, when loaded, just locks the output to Disabled, and will not change whatsoever.
The guys at tech support thought it might be an issue that my ports were USB 1.0 on my PowerMac, but I've double checked all the specs, and it's all USB 2.0.
I've run the factory reset on the MKII.
I've tried uninstalling and reinstalling the drivers.
Disconnecting all other USB devices.
Yet Cuemix remains stuck with disabled on the output selection.
As an extra test, I tried the MKII on a brand new Macbook I got on Friday, and it works fine (on Leopard as well).
Have you guys got any ideas ?

Doing a wipe of my PowerMac computer is a real unwanted last resort that is all I can think of, and I'd much rather find the bug that is causing this.