Hey I just want to say I'm also having this issue.
A few months ago it was working fine.
I kinda suspect it was a Win10 update, as I hadn't changed MOTU driver/software version in ages, and it was working up until fairly recently.
Also, an aside, but there is no serial on the device, meaning I can't register a product via the MOTU website, and frankly as someone who only uses it once in a blue moon to practice guitar it's kinda unappealing having to go to that much effort (I could barely be even bothered to register here).
Here's what I've tried so far:
- Running the latest MOTU Microbook II installer as admin
- Running the latest MOTU Microbook II installer as admin with all combinations of options (firewire || pci || microbook, firewire && pci && microbook), etc
- Disabling the device in device manager, looking for updated drivers, pointing at the install directory (I don't think it can find the drivers from a .exe anyway)
- Installing random old versions of the MOTU Microbook II installer
- All USB ports available on my PC (5x) (some USB 2, some USB 3)
- Reinstalling Win10
The best/worst part - the device works on my fiances laptop which runs like total dog $#@%

haha
Anyway my hopes of someone swooping in and understanding this well enough to help me resolve the issue is low, but hopefully this bumps it forward for someone else.
PC specs:
OS: Windows 10 home 64bit (all available updates installed - the issue??)
CPU: AMD Ryzen 5 2500X 6 core, 12 thread, model 8
RAM: 16GB, 1465.8 Mhz
GPU: Nvidia GeForce RTX 2060, A2
Mobo: B450 Gaming Pro Carbon AC (MS-7B85)
Without a driver installed, plugging it in doesn't seem to do much, it shows up under "Other devices" in device manager with a warning/exclamation symbol, as MicroBookII.
"The drivers for this device are not installed. (Code 28)
There are no compatible drivers for this device.
To find a driver for this device, click Update Driver."
Updating driver does nothing.
After installing the MOTU Hardware, it moves to sit under "Sound, video and game controllers" as 'MOTU MicroBook', temporarily.
When I unplug/replug the device, it then gives me:
"USB device not recognized"
"The last USB device you connected to this computer has malfunctinoed and Windows does not recognise it"
Details from the unrecognised device in Windows:
"Unknown USB Device (Configuration Descriptor Request Failed)"
"Windows has stopped this device because it has reported problems. (Code 43)
A request for the USB configuration descriptor failed."
Best of luck guys, I have had no luck with this