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I cant open my actual project of my host sequencer anymore in which I used machfive 3 and the uvi soundsource xtrem fx! It says "it must be closed" I tried it several times. I also tried to open an older version (it saves every 10 minutes automatically) but it is only a version of last week available! But it is hours of work which are really really important!
I opened a new project and realized that the uvi sound source xtrem fx is not available. Maybe because I had a license before I get machfive 3 of it??
Im in really big trouble if I cant open the project anymore...
What can I do?

Don't panic for one!

Startup DP holding the option key and disable all plugs. Then try enabling the plugs from the DP preferences. That will force DP to reexport the audio system.

If that doesn't work, remove the plugs from the system plugin folder (library>audio) and start DP. Quit DP and move the plugs back and start DP again. That will force a reexamination of the plugs.

If that fails, reinstall MachFive. You might also pitch the plists for DP and MachFive as well.

I had the original ExtremeFX as well and skipped that install from the M5 disk without a problem and I don't that is an issue. Were you ever able to see ExtremeFX in MachFive? Did it go south after that or are we talking about initial setup in M5?

Oh wait. What is your host sequencer?

(sry for my bad english)
thanks for your help! I appreciate it really and hope I can help you anytime!

I solved to start BUT no Xtrem FX liberary, I cant open it!
my host sequencer is studio one 2.

Update:
I transfered my older Xtrem FX Licence to another key and my sequencer works. Also machfive 3, BUT no xtrem FX.
So I activated the licence of xtrem FX of MachFive 3 and the old problem reappears, the sequencer dont start!
Wothout the licence MachFive cant open the liberary and dont find the used samples of Xtrem FX.
I reinstalled the liberary twice but not working!

Have you installed both UFS and UFS-1? They both need to be present. That about 9GB in all.