Hi avamark,
MS is microsoft, as said emmrecs.
For the MS patch, and install read the following:
The patch that really solves your PB is the
KB885222. I tried with SP1 without KB885222 -> it works, with SP2 without KB885222 -> doesn't work, with SP2 and KB885222 -> it works
If your OS is Windows XP with Service Pack 2 (SP2), and you've got an internet connection, update your system with windows update, the patch is contained in the updates. If your windows is a cracked version (or if not...

) download the patch here
http://support.microsoft.com/kb/885222/en-us in english, or here
http://support.microsoft.com/kb/885222/fr in french.
Read the article carefully and download the patch.
Maybe it is not necessary to uninstall MOTU drivers before installing the patch (I don't know which version of driver you want to install, the last 3.6.7.3 I guess, and how the differents driver versions interact with windows and his registerbase... so...), but it's more safe. so do the following:
First, uninstall your MOTU properly, for this

keep the MOTU plugged and on
1) kill the MFWAKeys.exe process
2) uninstall the MOTU drivers via start/programs/MOTU/uninstall icon, or via the "add/remove programs" panel (select MOTU audio, uninstall).
3) right clic on the "unknown device " ( Arrow your MOTU in fact, that's why I told you to keep your MOTU plugged and on to uninstall it

) in the device manager, and clic on uninstall. confirm.
Now you can switch off your 8pre and unplug it.
Install the patch, and
reboot.
Now don't pass this very important following step:
1. Click Start, click Run, type regedit, and then click OK.
2. Locate and then click the following registry subkey:
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Enum\PCI\1394_hc_hw_id\1394_instance_id\Device Parameters
(To locate the FireWire controller information, follow these steps:1. Open Device Manager. To do this, right-click My Computer on the Start menu, click Manage, and then click Device Manager under System Tools. You can also click Properties under My Computer, and then click Device Manager on the Hardware tab.
2. Locate your FireWire controller in the IEEE 1934 Bus host controllers section.
3. Right-click the FireWire controller entry, click Properties, and then click the Details tab.
4. Click Device Instance Id. You see a string of letters and numbers that is similar to the following:
PCI\VEN_104C&DEV_8020&SUBSYS_00D81028&REV_00\4&19FD8D60&0&60F0
The information between the two slash marks (\) is the ••œ1394_hc_hw_id". ••œVEN_104C&DEV_8020&SUBSYS_00D81028&REV_00••