Very laborious as I have so many plug-ins

I previously was on a MacMini i7 using a Firewire 828 Mk2, but as the new Mac Studio doesn’t have FW I have now connected a Midas MR18 via USB.
Now I am at my wits end as I am getting really loud crackling on the audio. Not just in DP but also when playing any audio from websites etc. Firefox or Safari, makes no difference.
I have googled this and have tried disconnecting all other peripherals etc but nothing worked until I discovered that I had an upgrade available from Ventura 13.6.5 to 13.6.6.
I installed that and my problem was solved, or so I thought.
Sadly, a day later, the crackling is back.
This is only happening with the Mac’s audio output set to use my Midas MR-18 over USB.
When I set the sound o/p to headphones the problem is not there and the audio is fine.
I am pretty sure that this is not anything wrong with the Midas box, and online I've seen some reference to audio problems with Ventura. Worryingly, I've seen a lot of other mentions of audio problems with Apple Silicon machines.
Should I upgrade to Sonoma? Will that help?
Should I buy a new MOTU USB interface?
I hope you can help me with this as it is making my new £3k computer unusable.
Long time DP user - currently running DP 11.23 on Mac Studio M2 Ultra 1TB 64 GB RAM and OS Ventura 13.6.6
Any help greatly appreciated, thanks.
Cheers, Dave