MOTU has released updated Windows 10 drivers for USB/Firewire devices. The version is v4.0.6.6814, released Oct. 28, 2015.
I've installed them and have begun working with them with my aging 8pre. They seem to work well.
MOTU ships new Windows 10 USB/Firewire Drivers
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Discussion related to installation, configuration and use of MOTU hardware such as MIDI interfaces, audio interfaces, etc. with Windows
Discussion related to installation, configuration and use of MOTU hardware such as MIDI interfaces, audio interfaces, etc. with Windows